4.7 Article

Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD

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NEUROLOGY
卷 61, 期 7, 页码 1000-1002

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000083992.28066.7E

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Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g. 168_ 185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population.

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