期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 68, 期 21, 页码 8042-8060出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo034607k
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资金
- NCRR NIH HHS [RR03037] Funding Source: Medline
- NIGMS NIH HHS [GM 60271] Funding Source: Medline
The synthesis of the northwest quadrant of Altromycin B is described. The preparation of the two epimers at the quaternary carbon of the 6-deoxy-C-altrose moiety in the northwest quadrant is accomplished starting from D-glucose. A key step of our synthetic sequence is the formation of the C-glycoside linkage via the Ramberg-Backlund reaction. Two different routes are explored, which differ mainly on the timing of the conversion of glucose to altrose, either before or after the preparation of the C-glycoside. The conformation behavior of variously substituted C-altropyranoside rings is also discussed.
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