期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 198, 期 8, 页码 1147-1156出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20030530
关键词
Helicobacter pylori; T cell epitopes; autoreactive T cells; mimicry; mucosal immunity
Autoimmune gastritis and Helicobacter pylori-associated gastric atrophy develop through similar mechanisms involving the proton pump H+,K+-adenosine triphosphatase as autoantigen. Here, we report that H. pylori-infected patients with gastric autoimmunity harbor in vivo-activated gastric CD4+ T cells that recognize both H+,K+-adenosine triphosphatase and H. pylori antigens. We characterized the submolecular specificity of such gastric T cells and identified cross-reactive epitopes from nine H. pylori proteins. Cross-reactive H. pylori peptides induced T cell proliferation and expression of T helper type I functions. We suggest that in genetically susceptible individuals, H. pylori infection can activate cross-reactive gastric T cells leading to gastric autoimmunity via molecular mimicry..
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