期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 20, 页码 3623-3626出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(03)00755-8
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Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum caspase inhibitors have been identified. Their efficacy in cellular models of cell death and inflammation are also discussed. (C) 2003 Elsevier Ltd. All rights reserved.
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