期刊
MOLECULAR BRAIN RESEARCH
卷 118, 期 1-2, 页码 160-165出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbrainres.2003.08.002
关键词
central sensitization; glutamate receptor phosphorylation; intradermal capsaicin injection; nociception
资金
- NINDS NIH HHS [NS 11255, NS 09743] Funding Source: Medline
The present project was designed to investigate the role of protein kinase A (PKA) and protein kinase C (PKC) in the regulation of phosphorylation of the GluR1 subunits of AMPA receptors in the spinal cord of rats after capsaicin injection. We found that after capsaicin injection, a significant upregulation of phosphorylated GluR1 both at Ser(831) and Ser(845) was detected on the side ipsilateral to the injection. Intrathecal treatment with a PKA inhibitor, H89 ({N-[2-((3-bromophenyl)-2-propenyl)amino)ethyl]-5-isoquinoline sulfonamide, HQ, or a PKC inhibitor, NPC15473 (2,6-diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide), significantly blocked the increased phosphorylation at different serine sites without affecting the GluR1 protein itself Our results suggest that increased phosphorylation of the GluR1 subunit of AMPA receptors contributes to central sensitization following acute peripheral inflammation, and the effect may occur at different phosphorylation sites through the activation of the PKA or PKC protein kinase cascades. (C) 2003 Elsevier B.V. All rights reserved.
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