期刊
NEUROSCIENCE LETTERS
卷 350, 期 2, 页码 113-116出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00898-X
关键词
neprilysin; amyloid beta 1-40; amyloid beta 1-42; monomer; oligomer
Amyloid beta-peptide (Abeta) is widely believed to play a central role in Alzheimer's disease (AD). Coordinate regulation of cerebral Abeta level is important in the pathogenesis of AD since either increased production of Abeta from amyloid precursor protein or decreased degradation causes elevated levels of Abeta, leading to accumulation of cerebral plaque formation or amyloid angiopathy. Here we studied neprilysin, a putative proteolytic enzyme for Abeta, and found that it degraded not only monomeric but also oligomeric forms of Abeta1-40. Moreover, neprilysin was found to be capable of degradation of the oligomeric form of Abeta1-42, a significant Abeta species in early pathogenesis. Neprilysin to decrease cerebral Abeta is suggested to be inevitable factor as a vital therapeutic target. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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