期刊
BRAIN RESEARCH
卷 988, 期 1-2, 页码 69-77出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)03345-6
关键词
amyloid P; Alzheimer's disease; neurodegeneration; nuclear localization; apoptosis; beta-amyloid
资金
- NICHD NIH HHS [R01 HD017013] Funding Source: Medline
dPreviously we have reported serum amyloid P component (SAP) induced cell death in cerebro-cortical cultures of rat brain. In this paper we studied the types of target cells and the molecular mechanism of SAP-induced cell death. Immuno-electron and light microscopy revealed that SAP penetrates the plasma membrane and translocates selectively into the nuclei of neurons. Neuronal cells with SAP immunoreactivity exhibit the morphological hallmarks of apoptosis in vitro. The apoptotic mechanism of cell death is also supported by the increased Bax/Bcl-2 ratio. In addition to neurotoxic effects, we detected elevated beta-amyloid (Abeta) immunoreactivity following SAP treatment. This study supports the thesis that SAP plays an important role in the pathomechanism of neurodegenerative diseases, including Alzheimer's disease by inducing neuronal apoptosis. (C) 2003 Elsevier B.V. All rights reserved.
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