期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 100, 期 22, 页码 12642-12647出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2133947100
关键词
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资金
- NCI NIH HHS [R01 CA058554, R01 CA 78797, R01 CA 58554] Funding Source: Medline
- NIA NIH HHS [R01 AG078797] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 62694, R01 GM062694] Funding Source: Medline
Pulmonary adenoma susceptibility 1 (Pas1), located on chromosome 6, is the major locus affecting inherited predisposition to lung tumor development in mice. We have fine mapped the Pas1 locus to a region of approximate to0.5 megabases by using congenic strains of mice, constructed by placing the Pas1 region of chromosome 6 from A/J mice onto the genetic background of C57BL/6J mice. Systematic characterization of Pas1 candidates establishes the Las1 (lung adenoma susceptibility 1) and Kras2 (Kirsten rat sarcoma oncogene 2) genes as primary candidates for the Pas1 locus. Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity.
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