期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 479, 期 1-3, 页码 83-91出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2003.08.059
关键词
dopamine transporter; norepinephrine transporter; protein kinase C; dopamine release; PC12 cell; striatum
资金
- NIDA NIH HHS [DA11697, DA13417] Funding Source: Medline
Amphetamine elicits its locomotor-activating and drug-reinforcing effects by releasing the catecholamines dopamine and norepinephrine into the synapse. Amphetamine is a substrate of the plasmalemmal transporters for both dopamine and norepinephrine. As such, it binds to the transporters in conjunction with Na+ and Cl-, facilitating a conformational change leading the transporter to face inward. The subsequent binding of intracellular catecholamine results in an outward transport and release of the catecholamine into the synapse. Both inward and outward transport through the catecholamine transporters are regulated by protein kinases, particularly protein kinase C, but the effect of the enzyme on the two processes appears to be asymmetric. The purpose of this review is to discuss the evidence showing that protein kinase C activation facilitates outward transport through the catecholamine plasmalemmal transporters which may mediate amphetamine action in intact tissue. (C) 2003 Elsevier B.V. All rights reserved.
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