期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 479, 期 1-3, 页码 283-289出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2003.08.077
关键词
vesicular monoamine transporter; amphetamine; methylphenidate; cocaine
资金
- NIDA NIH HHS [DA00869, DA04222, DA13367, DA 11389] Funding Source: Medline
The vesicular monoamine transporter-2 (VMAT-2) facilitates the sequestration of catecholamines and serotonin into synaptic vesicles, and is therefore an essential regulator of monoaminergic neuronal function. VMAT-2 proteins may also play a role in neuroprotection, since these transporters have the capacity to sequester neurotoxins within vesicles. Recent studies have demonstrated that psychostimulants, particularly dopamine releasers and reuptake inhibitors, differentially alter VMAT-2 function. As described in this review, these studies not only provide insight into the pharmacological actions of stimulants, but also mechanisms underlying neurodegenerative disorders, including Parkinson's disease. (C) 2003 Elsevier B.V. All rights reserved.
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