期刊
INFECTION AND IMMUNITY
卷 71, 期 11, 页码 6620-6623出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.11.6620-6623.2003
关键词
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资金
- NIAID NIH HHS [R01 AI052059, R01 AI52059, R01 AI 43680] Funding Source: Medline
Antibodies that inhibit Plasmodium falciparum adhesion to the placental receptor chondroitin sulfate A are associated with a reduced risk of placental malaria, but whether these antibodies lead to improved pregnancy outcomes is unknown. We measured antiadhesion antibody levels in parturient women in western Kenya, where malaria transmission is intense. Secundigravid women with antiadhesion activity in their plasma delivered babies that were on average 398 g heavier (P = 0.019) and 2 weeks more mature (P = 0.002) than babies delivered to secundigravidas without antiadhesion activity. Our findings support the development of antiadhesion vaccines to prevent poor fetal outcomes due to pregnancy malaria.
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