期刊
PEPTIDES
卷 24, 期 11, 页码 1723-1731出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2003.07.025
关键词
cathelicidin peptide; alpha-helical antimicrobial peptide; synthetic analog; antimicrobial activity; clinical isolate; in vivo protection; infection
Two alpha-helical antimicrobial peptides (BMAP-27 and -28) and four synthetic analogs were compared for in vitro and in vivo antimicrobial efficacy. All peptides proved active in vitro at micromolar concentrations against a range of clinical isolates, including antibiotic-resistant strains. BMAP-27 and two analogs were more effective towards Gram-negative, and BMAP-28 towards Gram-positive organisms. In addition, BMAP-28 provided some protection in vitro against human herpes simplex virus type 1 (HSV-1). The parent peptides and mBMAP-28 analog protected mice from lethal i.p. infections in an acute peritonitis model at peptide doses significantly lower than those toxic to the animals, suggesting a satisfactory therapeutic index. (C) 2003 Elsevier Inc. All rights reserved.
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