期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 10, 页码 5736-5747出版社
AMER CHEMICAL SOC
DOI: 10.1021/am507898z
关键词
thermosensitive magnetoliposomes; gold nanoshells; dual-mode MR/X-ray imaging controlled release; chemo-hyperthermia therapy
资金
- National Natural Science Foundation of China [81302717, 81273451]
- China Postdoctoral Science Foundation [2014M562002]
- Youth Teacher Development Foundation of Zhengzhou University [1421331073]
In this study, a new type of magnetic tuniot-targeting P-B-Gylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes Was successfully obtaitied. The reversephase evaporation method was used to construct the magnetoliposorneS, and then gold nanoShells were coated on the Surface Of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG(2000) modification. This rimItifunction system was combined with a variety of functions, such as radiofrequenty-triggered release, cherno-hyperthermia therapy, and dual-Mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AUNSs-PEG Complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosornal degradation. All results in vitro and in vivo indicated that DOX=TSMLs,AuNSs-PBG is a promising effective drug delivery system for diagnosis and treatment of tumors.
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