Methods to initiate synthetic re-structuring of peptides

Sculpture during assembly is an appropriate description of procedures used to transform unprotected peptide i into complex macrocycle ii. These methods appear a general means to begin manipulating the form and characteristics of common polyamides. Herein we demonstrate initial phases of a type of synthesis that has the potential to produce large numbers of novel structural classes beginning with machine-made heteropolymers. (C) 2003 Elsevier Ltd. All rights reserved.