Direct proline catalyzed asymmetric α-aminooxylation of aldehydes

The direct catalytic enantioselective alpha-aminooxylation of aldehydes has been developed using nitrosobenzene as the oxygen source and L-proline as catalyst, affording versatile alpha-aminooxylated aldehydes in high yield with excellent enantioselectivities. (C) 2003 Elsevier Ltd. All rights reserved.