期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 198, 期 9, 页码 1349-1360出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20030381
关键词
Helicobacter pylori; antigenic variation; genome plasticity; pathogenicity island; type IV secretion system
资金
- NCI NIH HHS [5 T32 CA09385, T32 CA009385] Funding Source: Medline
- NIAID NIH HHS [T32 AI007180, 5 T32 AI07180-20] Funding Source: Medline
- NIGMS NIH HHS [R01 GM063270, R01 GM63270] Funding Source: Medline
DNA rearrangement permits bacteria to regulate gene content and expression. In Helicobacter pylori, cagY, which contains an extraordinary number of direct DNA repeats, encodes a surface-exposed subunit of a (type IV) bacterial secretory system. Examining potential DNA rearrangements involving the cagY repeats indicated that recombination events invariably yield in-frame open reading frames, producing alternatively expressed genes. In individual hosts, H. pylori cell populations include strains that produce CagY proteins that differ in size, due to the predicted in-frame deletions or duplications, and elicit minimal or no host antibody recognition. Using repetitive DNA, H. pylori rearrangements in a host-exposed subunit of a conserved bacterial secretion system may permit a novel form of antigenic evasion.
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