期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 125, 期 44, 页码 13382-13386出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja030087z
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资金
- NIAID NIH HHS [R01 AI036596, P30 AI050409, 2P30-AI-50409] Funding Source: Medline
- PHS HHS [1R01A136596, 5K02A101502] Funding Source: Medline
Two novel alkaloids, named manadomanzamines A (1) and B (2), were isolated from an Indonesian sponge Acanthostrongylophora sp. (Haplosclerida: Petrosiidae). Their structures were elucidated and shown to be a novel organic skeleton related to the manzamine type alkaloids. Their absolute configuration and conformation were determined by CID, NOESY, and molecular modeling analysis. The microbial community analysis for the sponge that produces these unprecedented alkaloids has also been completed. Manadomanzamines A (1) and B (2) exhibited strong activity against Mycobacterium tuberculosis (Mtb) with MIC values of 1.9 and 1.5 mug/mL, respectively. Manadomanzamines A and B also exhibit activities against human immunodeficiency virus (HIV-1) and AIDS opportunistic fungal infections.
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