期刊
FEBS LETTERS
卷 554, 期 1-2, 页码 138-142出版社
WILEY
DOI: 10.1016/S0014-5793(03)01129-3
关键词
diabetes mellitus; hyperglycemia; oxidative DNA damage; glyceraldehyde; 3-deoxyglucosone
Increased risks of cancers and oxidative DNA damage have been observed in diabetic patients. Many endogenous aldehydes such as 3-deoxyglucosone and glyceraldehyde (GA) increase under hyperglycemic conditions. We showed that these aldehydes induced Cu(II)-mediated DNA damage, including 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation. GA had the strongest ability to damage DNA, and addition of low concentrations of H2O2 markedly enhanced the DNA damage. GA significantly increased 8-oxodG formation in human cultured cells (HL-60), and H2O2 enhanced it. We conclude that oxidative DNA damage by hyperglycemia-related aldehydes, especially GA, and marked enhancement of DNA damage by H2O2 may participate in diabetes-associated carcinogenesis. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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