期刊
SCIENCE
卷 302, 期 5647, 页码 1053-1056出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1089525
关键词
-
资金
- NCI NIH HHS [P01CA27489] Funding Source: Medline
- NIAID NIH HHS [5T32AI07606] Funding Source: Medline
- NIGMS NIH HHS [GM 43858] Funding Source: Medline
Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be critical to the pathogenesis of atherosclerosis, including cytotoxicity, lipid-loading in macrophages, and deformation of the apolipoprotein B-100 secondary structure. We propose the trivial designation atheronals for this previously unrecognized class of steroids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据