期刊
VACCINE
卷 21, 期 31, 页码 4545-4549出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00500-0
关键词
HIV; HBV vaccine; GM-CSF; vaccine adjuvant
Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is a cytokine with a potential vaccine adjuvant activity. It is also known that human immunodeficiency virus (HIV) infected patients often show poor immunologic responses to immunization. We examined whether the use of GM-CSF could augment the immunologic response to recombinant vaccine against the hepatitis B virus (HBV) in 80 HIV infected patients (18-35 years old). They received a double dose (40 mug) of recombinant HBV vaccine IM at 0, 1 and 6 months and were randomized to receive either concurrent 20 mug of GM-CSF (n = 40) or placebo IM (n = 40) with the first vaccine dose. A significant increase in the seroconversion rate was observed after the second vaccine dose in the GM-CSF group (62% GM-CSF versus 30% control group P < 0.0074). The average anti-HBs titers measured on days 28, 60 and 210 were 40.3; 366.5 and 644.8 milli-intemational units per milliliter (mIU/ml), respectively, in the GM-CSF group, and 62.4; 166.4 and 375.0 mIU/ml, respectively, in the control group, with significant differences at 60 and 210 days (P < 0.01). There were no significant differences between CD4/CD8 cells, viral load. risk factors, age, sex and the serological responses to the HBV vaccine. This study suggests that GM-CSF increases the immunogenicity of recombinant HBV vaccine in HIV infected individuals. (C) 2003 Elsevier Ltd. All rights reserved.
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