The role of urocortin in gynecological and obstetrical conditions

The objective of the review is to present the possible role of urocortin, a novel peptide of the corticotrophin releasing factor family, in different conditions of obstetrics and gynecology such as preterm labor, preeclampsia or ovarian steroidogenesis. A MEDLINE search was commenced with the terms urocortin, preterm labor, preeclampsia, ovary, endometrium, myometrium, placenta, plasma, amniotic fluid. Seventy-three articles were found to be relevant on the field and the potential role of urocortin in such conditions is presented. Amounting data suggest that urocortin could play a significant role in human reproduction (steroidogenesis in the ovary, maintenance of the placental function and labor). Further investigation on the field is necessary in order to clarify the natural role of this newly identified molecule in the field of obstetrics and gynecology.