Studies in the preparation of novel P-chirogenic binaphthyl monophosphanes (MOPs)

Several routes to P-chirogenic binaphthyl monophosphanes (MOPS) and their derivatives were investigated. Palladium catalysed coupling gave access to a new class of P-chirogenic phosphane oxides from which the phosphane can be obtained by reduction. Substituents on phosphorus strongly influence the efficiency of the P-C coupling reaction, which is only slightly stereo selective. (C) 2003 Elsevier Ltd. All rights reserved.