期刊
NEUROSCIENCE LETTERS
卷 351, 期 2, 页码 115-119出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00770-5
关键词
autonomic regulation; blood pressure; hypocretin; immunocytochemistry; superior cervical ganglion; spinal cord; ultrastructure
资金
- NIMH NIH HHS [MH62589, MH01507] Funding Source: Medline
Orexin increases blood pressure and orexin-immunoreactive (IR) axons robustly innervate the spinal cord. Seeking anatomical evidence for direct effects of orexin on sympathetic preganglionic neurons (SPN), we used immunohistochemistry to study the relationships between orexin-IR axons and SPN identified by immunoreactivity for choline acetyltransferase (ChAT) or for cholera toxin B retrogradely transported from the superior cervical ganglion (SCG). In the intermediolateral cell column (IML), varicose, orexin-positive axons closely apposed almost all SPN in segments T1 and T2, but appositions were rare in T4-L2. Orexin fibers also apposed ChAT-IR cell bodies in the intercalated nucleus and the central autonomic area from T1 to L2. Orexin-IR synapses were identified ultrastructurally on SPN projecting to the SCG. Since SPN involved in cardiovascular control cluster in the IML of mid- and lower thoracic cord, these findings suggest that orexin affects blood pressure by acting on supraspinal neurons rather than SPN. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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