期刊
BIOCHEMICAL PHARMACOLOGY
卷 66, 期 10, 页码 2021-2028出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0006-2952(03)00544-6
关键词
oxidative stress; redox catalysts; chemotherapy; zinc finger; cyclic voltammetry
Tumor cells proliferate under conditions of oxidative stress. A novel therapeutic approach would be to enhance the cellular effects of the reactive oxygen species formed under these conditions by supplementation with a redox catalyst. This provides a means to target and specifically destroy cancer cells via oxidation of redox-sensitive proteins, such as transcription factors, while leaving cells with a normal redox balance largely unaffected. We have previously reported a preliminary observation on the effects of pro-oxidant catalysts that enhance cancer cell death. This paper presents a detailed in vitro investigation into the mechanism of action of synthetic glutathione peroxidase mimics on a model Sp1 transcription factor peptide. The structure and redox potential of these mimics correlate with their ability to catalyze the oxidation of this zinc-binding motif by H2O2 and these compounds promise therapeutic potential by promoting H2O2-induced PC12 cell death. (C) 2003 Elsevier Inc. All rights reserved.
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