期刊
ARCHIVES OF GERONTOLOGY AND GERIATRICS
卷 59, 期 3, 页码 665-669出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2014.07.002
关键词
Oxidative stress; Aging; Intervertebral disc; Nitrogen monoxide; Superoxide dismutase; Malondialdehyde
资金
- National Natural Science Foundation of China [81272040, 30600632]
- Natural Science Foundation of Guangdong Province, China [S2011010004808]
Aging is a major factor associated with lumber intervertebral disc degeneration, and oxidative stress is known to play an essential role in the pathogenesis of many age-related diseases. In this study, we investigated oxidative stress in intervertebral discs of Wistar rats in three different age groups: youth, adult, and geriatric. Age-related intervertebral disc changes were examined by histological analysis. In addition, oxidative stress was evaluated by assessing nitric oxide (NO), superoxide dismutase (SOD), malondialdehyde (MDA), and advanced oxidation protein products (AOPPs). Intervertebral disc, but not serum, NO concentrations significantly differed between the three groups. Serum and intervertebral disc SOD activity gradually decreased with age. Furthermore, both serum and intervertebral disc MDA and AOPP levels gradually increased with age. Our studies suggest that oxidative stress is associated with age-related intervertebral disc changes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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