期刊
BIOLOGICAL PSYCHIATRY
卷 54, 期 10, 页码 1006-1014出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(03)00700-5
关键词
antidepressant; Wnt signaling; immunohistochemistry; seizure
资金
- NIMH NIH HHS [MH45481, 2P01 MH25642] Funding Source: Medline
Background: Beta-catenin was discovered as a cytoskeletal protein, constituting a link between the cadherins to the actin cytoskeleton. Aside from this function, beta-catenin is a key effector molecule in the Wnt signaling pathway, serving as a downstream transcription factor. Methods: In this study, we examined the influence of electroconvulsive seizures (ECS) on the expression of beta-catenin, as well as expression of Wnt-2, in rat hippocampus. Repeated administration of generalized seizures increased levels of beta-catenin immunoreactivity in the subgranular zone of the hippocampus. To assess the relationship of beta-catenin to cell division in the dentate gyrus of the adult rat hippocampus, colocalization of beta-catenin with a marker of cell division was examined. Results: Beta-catenin immunoreactivity was consistently localized in newborn cells in this region, indicating a possible role in cell division and differentiation in adult hippocampus. We also found that ECS treatment significantly increased levels of Wnt-2, one of the ligands that activates beta-catenin signaling. Conclusions: These results demonstrate that ECS increases Wnt-beta-catenin signaling and suggest that this pathway could mediate in part the neuronal adaptations underlying the therapeutic action of this treatment paradigm. Biol Psychiatry 2003;54:1006-1014 (C) 2003 Society of Biological Psychiatry
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