期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 419, 期 2, 页码 120-128出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.abb.2003.08.031
关键词
atherosclerosis; LPS; liver; sphingomyelinase; sphingosine
资金
- NCRR NIH HHS [M01 RR 02602] Funding Source: Medline
Recent studies have indicated that ceramide generated in the liver is secreted into the bloodstream as component of very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL). This manuscript investigates the effect of host acute phase response to inflammation on lipoprotein ceramide levels. In humans, two different patterns of responses were found. One group of volunteers experienced transient increases in serum ceramide at 1.5 h after LPS administration. Second group showed prolonged increases that reached up to 10-fold above the basal level and continued for up to 24 h. Increases in ceramide were found only in VLDL and LDL particles. LPS administration induced similar increases in mice. These increases were accompanied by activation of secreted sphingomyelinase in serum and serine-palmitoyl transferase in liver. ASMase knockout mice retained LPS-induced increases in serum ceramide, thus suggesting that the elevation of VLDL and LDL ceramide content is attributed at least in part to activation of de novo synthesis of ceramide in the liver. (C) 2003 Elsevier Inc. All rights reserved.
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