期刊
TOXICOLOGY
卷 193, 期 1-2, 页码 43-65出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0300-483X(03)00289-0
关键词
base excision repair; reactive oxygen species; DNA
资金
- NCI NIH HHS [CA98664, CA81063, CA53791] Funding Source: Medline
The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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