期刊
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
卷 329, 期 3-4, 页码 451-458出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-4371(03)00574-0
关键词
Potts model; diffusion; cell motion
Because the extended or cellular large-Q Potts model (CPM) captures effectively the global features of tissue rearrangement experiments, including cell sorting and tissue engulfment, it has become a common technique for cell level simulation of tissues. However, it omits three key elements of real cells, their fixed membrane area, their attractive binding and the dissipation of making and breaking membrane contacts. In this paper, we modify the Hamiltonian to use negative surface energies, constrained surface area and a spin flip energy threshold to improve the correspondence to reality. We find that the new model correctly predicts several dynamical behaviors of cells which the original CPM does not, including the hierarchy of diffusion constants. (C) 2003 Published by Elsevier B.V.
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