Inhibitors of hepatitis C virus NS3•4A protease 1.: Non-charged tetrapeptide variants

Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P-1 and P-2 inhibitor positions is discussed. (C) 2003 Elsevier Ltd. All rights reserved.