期刊
TETRAHEDRON
卷 59, 期 47, 页码 9305-9313出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2003.09.092
关键词
macrolactin; iron-tricarbonyl complex; antibiotics; antivirus; synthesis
The stereoselective synthesis of the two segments 3 and 4 of macrolactin A I is described. Macrolactin A is a 24-membered polyene macrolide antibiotic, which is of interest due to a strong activity against B16-F10 murine tumor cell and HIV-1 virus. The key step of the synthesis is the 1,2-migration reaction of a (diene)Fe(CO)(3) complex with a introduction of the thiol group to construct the unstable (E,Z)-conjugated dienic moiety (C8-C11). (C) 2003 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据