期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 198, 期 10, 页码 1453-1462出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20031484
关键词
membrane microdomains; Lck; Csk; signal transduction; phosphorylation
资金
- Wellcome Trust Funding Source: Medline
Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. Thus, LIME appears to be involved in regulation of T cell activation by coreceptors.
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