期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 22, 页码 4043-4046出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2003.08.033
关键词
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The synthesis and pharmacological evaluation of a new series of potent P2X(7) receptor antagonists is disclosed. The compounds inhibit BzATP-mediated pore formation in THP-1 cells. The distribution of the P2X(7) receptor in inflammatory cells, most notably the macrophage, mast cell and lymphocyte, suggests that P2X(7) antagonists have a significant role to play in the treatment of inflammatory disease. (C) 2003 Elsevier Ltd. All rights reserved.
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