期刊
JOURNAL OF CONTROLLED RELEASE
卷 93, 期 1, 页码 15-28出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(03)00359-6
关键词
agglomerated vesicle technology; aerosol drug delivery; controlled and modulated release; liposomes; ciprofloxacin
A new class of pulmonary delivery particles is described. These particles consist of multimicron sized chemically linked agglomerates of core nanoparticles. The links between the nanoparticles can be either permanent (e.g. carbonyl) or cleavable (e.g. disulfide or ester). Complex agglomerate structures can be achieved by scheduling the application of linker agents. The release rate of drugs from the assembly can be modulated by controlling the extent of cleavage of the links. One envisions the structure of the agglomerate during cleavage being controlled by the location of the permanent and cleavable links in the agglomerate. Data on the release of ciprofloxacin from these agglomerates in vitro are presented. (C) 2003 Published by Elsevier B.V.
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