期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 125, 期 46, 页码 14120-14125出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja036191y
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The total synthesis of (+)-hapalindole Q has been achieved. The key step is a Diels-Alder reaction mediated by MacMillan's organocatalyst to provide the critical intermediate with high enantioselectivity (93% ee). This step establishes the proper arrangement of the required four contiguous stereocenters, including the quaternary center, and represents the first successful application of an enantioselective organomediated Diels-Alder reaction in total synthesis.
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