期刊
ARCHIVES OF GERONTOLOGY AND GERIATRICS
卷 48, 期 2, 页码 151-154出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2007.12.004
关键词
Cell-aging; Senescence-associated-beta-galactosidase; Maillard reaction; Rhamnose-rich oligo- and polysaccharides; Skin aging
资金
- Institut DERM
- NATURA Ltda
- Ophthalmology department
Expression by cells of the SA-beta-Gal was shown to be a reliable indicator of the switch mechanism used by cells to enter the senescent phenotype. We used this method in order to explore the variation of SA-beta-Gal-positive cells with passage number and time spent in culture. Both parameters produced an increase of SA-beta-Gal-positive cells. The addition of a Maillard-product (advanced glycation end-product=AGE) to the fibroblast cultures also increased SA-beta-Gal expression. Fucose- and rhamnose-rich oligo- and polysaccharides (FROPs and RROPs, respectively) provided a significant protection against this AGE-induced increase of SA-P-Gal-positive cells. It is speculated that these processes might well play an important role in skin aging. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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