期刊
ARCHIVES OF GERONTOLOGY AND GERIATRICS
卷 49, 期 1, 页码 E67-E71出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2008.09.001
关键词
Antioxidant defense system; Oxidative stress; Physical activity; Postmenopausal women
The aim of the study was to assess the influence of an 8-week aerobic physical activity program on oxidative stress markers, antioxidant parameters, and selected metabolic parameters in healthy, postmenopausal women. The study was carried out in a group of 41 healthy women (mean age 65 years) participating in an 8-week cycle ergometer physical workout of moderate intensity. Before and after completing the training program, the following parameters were assessed: total antioxidant status (TAS) and concentrations of thiobarbituric acid reactive substances (TBARS) in plasma, serum levels of antibodies against oxidatively modified low-density lipoproteins (LDL) (oLAB), serum concentrations of glucose, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), insulin, and reduced glutathione (GSH) concentrations in red blood cells (RBC). Atherogenic index of plasma (AIP) and insulin resistance index (HOMA(IR)) were calculated. The 8-week aerobic physical activity program resulted in significant decrease (p < 0.01) in serum glucose and LDL-cholesterol (LDL-C) levels, plasma TBARS concentrations (p < 0.05), and in significant decrease of HOMA(IR) (p < 0.01). TAS of plasma and GSH concentrations in RBC increased significantly (p < 0.01) over the study period. The results show that an 8-week aerobic training enhanced insulin sensitivity, and improved the balance between oxidants and antioxidants in healthy, postmenopausal women. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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