期刊
CANCER LETTERS
卷 201, 期 2, 页码 133-137出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(03)00466-X
关键词
Angelica keiskei; umbelliferae; chalcones; coumarins; flavanones; chemopreventive effects; antitumor-promoter; Epstein-Barr virus; antitumor-initiator
类别
资金
- NCI NIH HHS [CA 177625] Funding Source: Medline
From an ethyl acetate-soluble fraction of the exudate obtained from the stems of Angelica keiskei (Umbelliferae), 17 compounds, viz. five chalcones (1-5), seven coumarins (6-12), three flavanones (13-15), one diacetylene (16), and one 5-alkylresorcinol (17), were isolated. These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor-promoters. With the exception of three compounds (10, 16, and 17), all other compounds tested showed potent inhibitory effects on EBV-EA induction (92-100% inhibition at 1 X 10(3) mol ratio/TPA). In addition, upon evaluation of these compounds for the inhibitory effects against activation of ( -)-(E)-methyl-2-[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for antitumor-initiators, two chalcones (2 and 3) and six coumarins (6-11) exhibited potent inhibitory effects. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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