4.5 Article

Preparation of [1,2,3,4,5-13C5]-5-amino-4-oxopentanoic acid (ALA) -: Design of a synthetic scheme to prepare any 13C- and 15N-isotopomer with high isotopic enrichment

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2003, 期 23, 页码 4654-4663

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200300408

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biosynthesis; isotopic labelling; NMR spectroscopy; amino acids

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5-Amino-4-oxopentanoic acid (5-aminolevulinic acid) is a precursor in the biosynthesis of the biologically active porphyrins such as chlorophyll, bacteriochlorophyll, heme, etc. These systems are central in photosynthesis, oxygen transport, electron transport, etc. In this paper we describe a simple scheme to prepare any isotopomer of 5-aminolevulinic acid in a few steps in high yield. Using a similar scheme, levulinic acid can now also be prepared in any isotopomeric form. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

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