期刊
ENDOCRINOLOGY
卷 144, 期 12, 页码 5430-5440出版社
ENDOCRINE SOC
DOI: 10.1210/en.2003-0331
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资金
- NIDDK NIH HHS [DK52018] Funding Source: Medline
- NIMH NIH HHS [MH64371] Funding Source: Medline
The lordosis reflex, a stereotypic posture adopted by female rats during sexual behavior, requires the convergence of a hormonal signal, estrogen, with a descending neural pathway from the ventromedial hypothalamic nucleus (VMH). The VMH contains at least three lordosis-relevant neural populations: estrogen receptor-alpha immunoreactive (ERalpha-IR) neurons, VMH neurons that project to the periaqueductal gray (PAG), and neurons that are ERalpha-IR and project to the PAG. Expression of Fos, a marker for neuronal activation, is increased in the VMH after mating. However, it is unknown which, if any, of these lordosis-relevant populations is activated. The majority of ERalpha-IR and projection neurons were not colocalized. Of the Fos-positive neurons, 41% neither contained ERalpha nor projected to the PAG, and 35% contained ERalpha but did not project to the PAG. Only 25% of Fos-positive neurons projected to the PAG, including projection neurons that expressed ERalpha. Our results suggest that mating activates several distinct VMH neuron types. However, ERalpha-IR neurons are activated to a greater extent compared with the PAG-projecting neurons.
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