期刊
ARCHIVES OF GENERAL PSYCHIATRY
卷 65, 期 5, 页码 586-594出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archpsyc.65.5.586
关键词
-
类别
Context: Children and adults with psychopathic traits and conduct or oppositional defiant disorder demonstrate poor decision making and are impaired in reversal learning. However, the neural basis of this impairment has not previously been investigated. Furthermore, despite high comorbidity of psychopathic traits and attention-deficit/hyperactivity disorder, to our knowledge, no research has attempted to distinguish neural correlates of childhood psychopathic traits and attentiondeficit/hyperactivity disorder. Objective: To determine the neural regions that underlie the reversal learning impairments in children with psychopathic traits plus conduct or oppositional defiant disorder. Design: Case-control study. Setting: Government clinical research institute. Participants: Forty-two adolescents aged 10 to 17 years: 14 with psychopathic traits and oppositional defiant disorder or conduct disorder, 14 with attention-cleficit/hyperactivity disorder only, and 14 healthy controls. Main Outcome Measure: Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging during a probabilistic reversal task. Results: Children with psychopathic traits showed abnormal responses within the ventromedial prefrontal cortex (Brodmann area 10) during punished reversal errors compared with children with attention-deficit/hyperactivity disorder and healthy children (P<.05 corrected for multiple comparisons). Conclusions: To our knowledge, this study provides the first evidence of abnormal ventromedial prefrontal cortex responsiveness in children with psychopathic traits and demonstrates this dysfunction was not attributable to comorbid attention-deficit/hyperactivity disorder. These findings suggest that reversal learning impairments in patients with developmental psychopathic traits relate to abnormal processing of reinforcement information.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据