期刊
JOURNAL OF IMMUNOLOGY
卷 171, 期 11, 页码 5727-5735出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.171.11.5727
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- NIAID NIH HHS [AI41576] Funding Source: Medline
- NIDDK NIH HHS [DK57932, DK45260] Funding Source: Medline
Based primarily on in vitro data, IL-2 is believed to be the key cytokine for initiation of the cell cycle of activated T cells. However, the role of IL-2 remains unresolved for T cell responses in vivo. We examined whether the absence of IL-2-mediated signaling in CD8 T cells affected initiation of proliferation. Our results conclusively demonstrated that initial division of Ag-specific CD8 T cells following priming was IL-2 independent, regardless of the context in which Ag was presented. In contrast, the latter stage of the proliferative phase was IL-2-dependent, particularly in nonlymphoid tissues. Thus, activated CD8 T cells initially undergo IL-2-independent proliferation, but reach a critical juncture where the requirement for IL-2 as a growth factor gains prominence.
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