期刊
CELL RESEARCH
卷 13, 期 6, 页码 429-442出版社
SCIENCE CHINA PRESS
DOI: 10.1038/sj.cr.7290185
关键词
Msx genes; craniofacial; tooth; cleft palate; suture; development; transcription factor; signaling molecule
类别
资金
- NIDCR NIH HHS [R01DE14044, R01DE12329, P60DE13076] Funding Source: Medline
Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the phenotypic abnormalities shown in knockout mice and in humans. This review summarizes studies on the expression, regulation, and functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice.
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