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CURRENT OPINION IN IMMUNOLOGY
卷 15, 期 6, 页码 709-717出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2003.09.016
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Several advances have been made regarding the regulation of lupus-associated autoantibodies, including the identification of factors that lead to their production in autoimmunity. Recent studies have further defined the receptor-editing mechanisms used to eliminate autoreactive B cells, and have shown that these may be altered in autoimmune mice. In addition, evidence that autoreactive B cells persisting in the periphery can be activated by both T-dependent and T-independent stimuli suggests potential pathways by which autoantibodies may arise in lupus.
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