期刊
INFECTION AND IMMUNITY
卷 71, 期 12, 页码 7211-7214出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.12.7211-7214.2003
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资金
- NIAID NIH HHS [AI26815, R01 AI026815] Funding Source: Medline
Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.
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