期刊
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
卷 56, 期 6, 页码 620-628出版社
WILEY
DOI: 10.1046/j.1365-2125.2003.01946.x
关键词
antioxidants; endothelial dysfunction; nitric oxide; nitrate tolerance; oxidative stress; renin-angiotensin system
Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.
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