期刊
CANCER AND METASTASIS REVIEWS
卷 22, 期 4, 页码 359-374出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1023725029589
关键词
focal adhesion kinase; signaling; cancer
类别
资金
- NCI NIH HHS [CA90901] Funding Source: Medline
- NIDCR NIH HHS [P60-DE13079] Funding Source: Medline
- NIGMS NIH HHS [GM59943] Funding Source: Medline
Since its initial discovery as a substrate and binding partner for the Src oncogene, a role for the focal adhesion kinase (FAK) in cancer has been speculated. In this review the clinical evidence correlating FAK overexpression with cancer and the experimental evidence demonstrating that FAK can control some phenotypes associated with cancer will be discussed. In addition, the emerging theme of interactions between the FAK and growth factor signaling pathways will be described. The evidence presented in this review provides a compelling case for a role for FAK in the pathology of human cancer.
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