期刊
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
卷 35, 期 6, 页码 507-532出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOBB.0000008023.11211.13
关键词
neurotoxicity; methylmercury; inorganic mercury; lead; polychlorinated biphenyls; solvents; synaptosomes; nerve terminal function; neuromuscular junction; ion channels
资金
- NIEHS NIH HHS [ES05822, ES03299] Funding Source: Medline
Voltage-gated Ca2+ channels are targets of the number of naturally occurring toxins, therapeutic agents as well as environmental toxicants. Because of similarities of their chemical structure to Ca2+ in terms of hydrated ionic radius, electron orbital configuration, or other chemical properties, polyvalent cations from aluminum to zinc variously interact with multiple types of voltage-gated Ca2+ channels. These nonphysiological metals have been used to study the structure and function of the Ca2+ channel, especially its permeability characteristics. Two nonphysiological cations, Pb2+ and Hg2+, as well as their organic derivatives, are environmental neurotoxicants which are highly potent Ca2+ channel blockers. These metals also apparently gain intracellular access in part by permeating through Ca2+ channels. In this review the history of Ca2+ channel block produced by Pb2+ and Hg2+ as well as other nonphysiological cations is traced. In particular the characteristics of Ca2+ channel block induced by these environmental neurotoxic metals and the consequences of this action for neuronal function are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据