期刊
JOURNAL OF LIPID RESEARCH
卷 44, 期 12, 页码 2356-2364出版社
ELSEVIER
DOI: 10.1194/jlr.M300233-JLR200
关键词
flow-mediated dilation; body fat distribution; glucose tolerance
Visceral fat has been associated with multiple cardiovascular disease (CVD) risk factors. The aim of this study was to identify anthropometrical measures most closely associated with some well-known CVD risk factors. Because most Asians at risk have normal body mass index (BMI) according to Western standards, we studied healthy nonobese Korean males (n = 102; age: 36.5 +/- 0.8 years, BMI: 23.8 +/- 0.2 kg/m(2)). Visceral fat area (VIA) at the fourth lumbar vertebra was associated with increased postprandial triglyceride (TG) response (r = 0.53, P < 0.001) and with plasma malondialdehyde (MDA) (r = 0.36, P < 0.01) and PGF2(alpha). (r = 0.24, P < 0.05). When matched for BMI and age, men with high VIA (HVFA) (greater than or equal to100 cm(2); n = 27) had higher blood pressure (P < 0.01), increased consumption of cigarettes (P < 0.01), and lower ratio of energy expenditure to calorie intake (P < 0.01) as compared with low VIA men (<100 cm(2); n = 27). Men with HVFA showed higher TG, glucose, and insulin responses following fat and oral glucose tolerance tests respectively higher plasma concentrations of MDA (P < 0.001), urinary PGF(2alpha). (P < 0.05), and lymphocytes deoxyribonucleic acid tail moments (P < 0.01). Conversely, HVFA was associated with lower testosterone, insulin-like growth factor-1, and brachial artery flow-mediated dilation (P < 0.001). In conclusion, our data indicate that visceral fat accumulation, even in nonobese men, is a major factor contributing to increased CVD risk.-Jang, Y., O. Y. Kim, H.J. Ryu,J. Y. Kim, S. IT Song,J. M. Ordovas, and J. H. Lee. Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men.
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