期刊
CURRENT MEDICINAL CHEMISTRY
卷 10, 期 24, 页码 2693-2703出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867033456404
关键词
nitric oxide; catecholamines; glutamate; neurotransmission; neurotoxicity; oxidative stress; reactive oxygen species; electron transfer; cell signaling; antioxidants
资金
- FIC NIH HHS [5T37TW00067] Funding Source: Medline
This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.
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